Magnetic Resonance Spectroscopy Metabolite Analysis in Different Meningioma Subtypes
Keywords:Meningioma subtypes, MR spectroscopy
Meningiomas are one of the most common lesions of the dura, some meningiomas have aggressive and poor prognosis, therefore surgeons need to evaluate them preoperatively for their therapeutic planning. As one of the advanced MR techniques, proton magnetic resonance spectroscopy (MRS) as a non-invasive, quantitative study to estimate metabolites within the tumor. Of all the known metabolites detected by MRS, creatine, glycine, alanine, lactate, choline, glutamine, glutamate, and the glutamine/glutamate complex are believed to be useful in differentiating meningiomas from other tumors and from normal brain.
This study present 3 different cases of patients with meningioma, based on histopathological analysis, they were respectively diagnosed as WHO Grade I Transitional meningioma, WHO Grade II Atypical meningioma and WHO Grade III Recurrent Anaplastic meningioma.
MRS findings in brain tumor would show decrease in NAA and a decrease in Cr, which showed in all of the three cases. In addition, Cho/Cr ratio was also increased, which was the highest ratio in the third case of anaplastic meningioma.
MRS may aid clinician in the diagnostic process as it showed the biochemical content of the lesion, especially Cho/Cr ratio which might be a useful proliferative parameter in anaplastic meningomas compared with the others.
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