Phytochemical, Compositions and Antioxidant Activities of Timor Sandalwood Oil (Santalum Album L.)
As Natural Antioxidant Agent And Potential Target Therapy for WAT Browning
Keywords:Sandalwood oil, phytochemicals, α-santalol, antioxidant activities, ferric reducing antioxidant power
Introduction; The phytochemical metabolites analysis, chemical composition and antioxidant activity of sandalwood oil (Santalum album L.) have shown that it can potentially act against free radicals and the browning effect of white adipose tissue. This study aimed to screen the phytochemical metabolites and antioxidant activity of Timor sandalwood oil.
Methods; Phytochemical metabolites analysis were identified flavonoids, terpenoids, tannins, alkaloids, and saponins and steroid. Chemical composition were analysis using Gas Chromatography-Mass Spectrometry analysis. Antioxidant activity were measured using the ferric reducing antioxidant power and 1,1-diphenyl-2-picrylhydrazyl methods. Gallic acid was used as the standard equivalent.
Results; Timor sandalwood oil contained flavonoids, steroid, terpenoids, and tannins metabolites. The main compositions were dominated by α-santalol (45.04%) and β-santalol (22.0%). Antioxidant activity found with FRAP and DPPH methods were 484.51 mg/L and 36 mg/L, respectively. The IC50 against FRAP and DPPH free radicals were 47.16% and 4.46%, respectively.
Conclusion; Timor sandalwood oil has antioxidant agent and contains compounds that are beneficial in activating WAT browning as a potential therapeutic target.
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